Research Projects

IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and  (II) the focused application of this pipeline to derive clinically...

With an increasingly growing population in Europe, cognitive impairments as well as heart diseases are a major social and health issue. 1.2 million people in Europe are affected by Parkinson's disease (PD) while Alzheimer’s disease remains one of the biggest global public health challenges our generation is facing, while Cardiovascular disease...

The JA will be contribute to public health programmes in Europe and develop Alzheimers disease (AD) and dementia prevention and care models in different European countries. The aim is to contribute to improvements in health by supporting and facilitating quality and efficiency of public health and healthcare policies and interventions. Synergy and...

Alzheimer’s disease (AD) affects over 35 million people worldwide and yet there are currently no medicines which slow down the progress of the disease. The ADAPTED project aims to boost the development of new medicines by investigating an area of AD research which has previously received little attention – the APOE gene. The APOE gene is a well...

Raman HT is a company expert on Raman Spectroscopy (RS) which has developed a revolutionary medical device to diagnose Alzheimer’s Disease (AD) in blood plasma for the first time. Currently, there are only two accurate methods to diagnose AD, expensive, invasive with multiple side effects. Positron Emission Tomography (PET) scans the patient’s...

Beta-amyloid (β-amyloid) deposition is considered to be a necessary - but not sufficient - step on the path towards Alzheimer’s disease (AD). Depiction of brain β-amyloid in vivo can support an early diagnosis, and even provide an opportunity for consider secondary prevention of AD. Currently, however, the value of β-amyloid PET remains elusive...

Cognitive and mental disorders such as Dementia, Alzheimer´s, depression and Parkinson's disease, some of them closely related to ageing populations, have high social and economic burden. Nowadays, neurologists, psychiatrists, psychologists, gerontologists and general practitioners rely on subjective, time-consuming semi-structured interviews and...

As part of the Innovation policy of Andalusian Region, Fundación Descubre (www.fundaciondescubre.es) with the University of Almeria, University of Cordoba, University of Granada, University of Huelva, University of Malaga, Pablo de Olavide University, University of Seville, Jaen University and National Research Council (CSIC), the Association of...

Dementia is caused by a range of illnesses and disorders that damage the brain either directly or indirectly. With the rise of the ageing population in the EU, dementia is becoming a serious problem. Digital health interventions have the potential to improve the accessibility and effectiveness of palliative care. Palliative care is an area where...

The BEDMOND project aims at developing an ICT-based system for an early detection of  Alzheimer’s disease and other neurodegenerative diseases, based on a behavioural change to approach and focused in elderly people while living at home in an Ambient Assisted Living  environment. With such an early detection health professionals can later on apply...

Alzheimer's disease (AD) is the most common age-related neurodegerative disorder, and one of the most devastating diagnoses that patients and their families can receive. Currently ~10 % of over 65 year old have AD, and the direct and indirect cost of its care is estimated to be >100 billion $ in the US alone and in the UK ~ €22M, and therefore...

DEMTEST has established a large European and global collaboration between national surveillance units and dementia research centres, facilitating cooperation between neurologists, neuropathologists and neuroscientists. We work on standardisation of tests that are currently available and harmonise their use between centers worldwide. We define...