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Alzheimer's disease apolipoprotein pathology for treatment elucidation and development


Start Date
End Date
Total Funding
€ 6 796 740
Funding Programme
European Countries Involved

Alzheimer’s disease (AD) affects over 35 million people worldwide and yet there are currently no medicines which slow down the progress of the disease. The ADAPTED project aims to boost the development of new medicines by investigating an area of AD research which has previously received little attention – the APOE gene. The APOE gene is a well-known risk factor for developing the disease, but precisely how this gene contributes to the risk of developing AD is not known. People who carry the APOE4 version of the gene have a considerably higher risk of developing AD. They also tend to develop the disease much earlier in life. However, the reasons for this are not well understood and therefore APOE has largely been ignored in the quest to find treatments for AD. By bringing together leading experts in a range of state-of-the-art technologies, including three research-intensive small and medium-sized enterprises (SMEs), ADAPTED hopes to gain better insights into the causes of AD, something that will in turn lead to better treatments for patients.

Project partners

Fundacio Ace

Abbvie Deutschland Gmbh & Co Kg

Biogen Idec Limited

Caebi Bioinformatica Sociedad Limitada

Agencia Estatal Consejo Superior Deinvestigaciones Cientificas

Dc Biosceinces Ltd

Erasmus Universitair Medisch Centrum Rotterdam

Janssen Pharmaceutica Nv

Kite Innovation (Europe)

Universiteit Leiden

Mimetas Bv

Universitatsklinikum Bonn

Klinikum Der Universitaet Zu Koeln

Modus Research And Innovation Limited

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).