Research Projects

This database contains information on EU funded dementia research projects, undertaken since 2007. It is the product of a mapping exercise of European funding programmes for dementia research conducted by Alzheimer Europe in 2020. This database is not an exhaustive resource of information. It contains information about European projects that are funded by European programmes including FP7, H2020, IMI, JNPD, AAL and EU Health.

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Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons

AGEMEC

Sporadic Alzheimer’s Disease (AD) accounts for the overwhelming majority of all AD cases and exclusively affects people at old age. However, mechanistic links between aging and AD pathology remain elusive. We recently discovered that in contrast to iPSC models, direct conversion of human fibroblasts into induced neurons (iNs) preserves signatures...
Funding Programme
Start Date
End Date
Total Funding
€ 1 499 565
European Countries Involved

Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients

iNtoPoreAge

I am a stem cell biologist specialized on modeling human neurodegenerative diseases. During my PhD with Dr. O. Brüstle (University of Bonn), I was trained in human stem cell and reprogramming technologies working on human models for Alzheimer’s Disease (AD). As a postdoc at the Salk Institute with Dr. F. H. Gage, I acquired and strong foundation in...
Funding Programme
Start Date
End Date
Total Funding
€ 178 157
European Countries Involved

BEHAVIOUR PATTERN BASED ASSISTANT FOR THE EARLY DETECTION AND MANAGEMENT OF NEURODEGENERATIVE DISEASES

BEDMOND

The BEDMOND project aims at developing an ICT-based system for an early detection of  Alzheimer’s disease and other neurodegenerative diseases, based on a behavioural change to approach and focused in elderly people while living at home in an Ambient Assisted Living  environment. With such an early detection health professionals can later on apply...

Funding Programme
Start Date
End Date
Total Funding
€ 2 379 179
European Countries Involved

BRain Imaging, cognition, Dementia and next generation GEnomics: a Transdisciplinary approach to search for risk and protective factors of neurodegenerative disease

BRIDGET

Establishing efficient prevention strategies for dementia and Alzheimer's disease is a major health priority. Since the cascade of events leading to Alzheimer's disease begins many years before the disease is detected, efficient prevention should be initiated early.

This requires identifying individuals in the general population who are at high...

Funding Programme
Start Date
End Date
Total Funding
€ 3 111 460
European Countries Involved

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

CaSR Biomedicine

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular...
Funding Programme
Start Date
End Date
Total Funding
€ 3 657 195

Coaching system for functional exercise training of frail people with dementia

CO-TRAIN

Frailty leads to reduced competence in activities of daily living, independence, as well as secondary health problems and threats, e.g. falls, depression, anxiety and isolation. Frailty in persons with dementia interacts within a “vicious circle”, promoting physical decline. CO-TRAIN will develop a coaching system for functional exercise training...
Funding Programme
Start Date
End Date
Total Funding
€ 2 660 000
European Countries Involved

Common mechanisms and pathways in Stroke and Alzheimer's disease.

CoSTREAM

Common mechanisms and pathways in Stroke and Alzheimer's disease. It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists...
Funding Programme
Start Date
End Date
Total Funding
€ 5 100 373
European Countries Involved

Composition and dynamics of stress granules in cerebral organoid models of frontotemporal dementia

FTD-Organoids

Frontotemporal dementia (FTD) is the second most common form of dementia. A pathological hallmark is the formation of protein aggregates that consist mainly of Tau or TDP43. Patients suffer from the degeneration of the frontal and temporal lobes with no effective treatments being available. The recent advancement of 3D brain organoid cultures grown...
Funding Programme
Start Date
End Date
Total Funding
€ 174 167
European Countries Involved

DayGuide

DayGuide

DayGuide introduces a novel ICT-based system, supporting older adults suffering from mild cognitive impairment and early dementia in their daily life and their families. The system also supports persons living alone with no care person available on a regular basis. Persons with cognitive impairment experience various domestic challenges, depriving...
Funding Programme
Start Date
End Date
Total Funding
€ 2 200 000
European Countries Involved

Development of a late-onset-Alzheimer’s disease (LOAD) profile for accurate diagnosis and identification of potential therapeutic approaches

LOAD PROFILE

Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem...

Funding Programme
Start Date
End Date
Total Funding
€ 747 300
European Countries Involved

EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances

EURIPIDES

'We aim develop in-vivo imaging biomarker of multidrug transporter function as a generic tool for the prediction, diagnosis, monitoring and prognosis of major CNS diseases, as well as to provide support and guidance for therapeutic interventions. Multidrug transporters actively transport substrates (including multiple CNS drugs) against...

Funding Programme
Start Date
End Date
Total Funding
€ 9 086 523
European Countries Involved

eWall for Active Long Living

eWALL

Independent living of senior citizens is one of the main challenges linked to the ageing population, due to the impact on: (a) the life of the elderly people, (b) the national health systems, (c) the insurance companies, (d) the relatives and (e) the care-givers. Senior citizens may suffer from a number of diseases, including the decline in...
Funding Programme
Start Date
End Date
Total Funding
€ 8 838 005
 
Acknowledgement
Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).