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Common mechanisms and pathways in Stroke and Alzheimer's disease.


Start Date
End Date
Total Funding
€ 5 100 373
Funding Programme
European Countries Involved
Common mechanisms and pathways in Stroke and Alzheimer's disease. It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD. This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.
Project partners
Mimetas Bv
Ludwig-Maximilians-Universitaet Muenchen
Universiteit Leiden
The Chancellor Masters And Scholarsof The University Of Cambridge
Universite De Geneve
Eibir Gemeinnutzige Gmbh Zur Forderung Der Erforschung Der Biomedizinischen Bildgebung
Universite De Bordeaux
Karolinska Institutet
Institut Pasteur De Lille Fondation
King'S College London
Erasmus Universitair Medisch Centrum Rotterdam
Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).