PROMINENT is a collaborative pan-European public-private partnership funded through the Innovative Health Initiative (IHI) for five years. It aims to create a digital platform for precision medicine to improve the diagnosis and treatment of neurodegenerative disease and co-morbidities. The overriding objective is to assist clinicians with individualised decision support in the evaluation of patients with suspected cognitive impairment. The following article reviews recent progress.
Data sharing scaled across the consortium. Most partners delivered datasets that are now in centralised cleaning and harmonisation alongside requested open-access cohorts (A4+LEARN, ADNI, AIBL, HABS-HD, NACC, NIFD & PDBP). Cohort images are being processed using the Combinostics Docker image. A panel of neuropsychology specialists is aligning cognitive scales to improve comparability.
Clinical and platform work advanced in parallel. An ARIA-detection algorithm is FDA pending and under CE-mark review. In the United States a new cDAT release added image reconstruction, an updated report, improved quantification and support for GE StarGuide scanners. Sites tested cCOG and A-IADL-Q within the PROMINENT cNeuro environment, and a clinician training programme is in development with videos and tool-specific documentation.
Multicentre studies moved into recruitment after ethics approvals at all sites. Enrolment began in June 2025. Planning for a pilot on real-world evidence collection is ongoing. Engagement and governance stayed active. Two newsletters were released and the World Alzheimer’s Month campaign ran. Dementia in Europe Magazine issue 49 featured a Lunch Debate article and an interview with Ini Umoh. The RP2 Annual Report was approved, the mid-term review took place on 15 October, work on project assessment is underway, preparations continue for the 21 November consortium meeting and Amendment 3 is in progress with deliverables quality tracking ongoing.
Linus Jönsson will present “Review of payment models: PROMINENT project” at the 9th IPECAD conference in Glasgow. Registrations are open: http://www.ipecad.org/conference