On 5 November, Tobias Hartmann of Saarland University presented the three-year results from the European study LipiDiDiet at the 13th Clinical Trials on Alzheimer’s Disease (CTAD) conference. The research results have also been recently published in the journal Alzheimer's & Dementia, the peer-reviewed journal of the Alzheimer’s Association.
The LipiDiDiet trial is a randomised, controlled, double-blind and multicenter study investigating the effects of Souvenaid on cognition, memory, brain atrophy and related measures in prodromal Alzheimer’s disease (AD). Souvenaid is a nutritional drink, developed by Nutricia, containing an active ingredient called Fortasyn Connect - a combination of fatty acids, vitamins and other nutrients.
311 participants aged 55 to 85 years received the nutritional intervention or the placebo (125 mL once‐a‐day drink) at 11 study sites in Finland, Germany, the Netherlands and Sweden. The research participants were followed for up to three years of intervention. Findings showed significant reductions in decline between the intervention and the control group over a treatment period of three years, as measured by the primary and secondary endpoints. The nutritional intervention slowed the decline on clinical and other measures related to cognition, function, brain atrophy and disease progression for the NTB 5‐item composite score, Clinical Dementia Rating‐Sum of Boxes (CDR-SB), memory and brain atrophy measures. The results also indicate that the benefits of this intervention increased with long-term use.
“We found that there was 20 percent less brain shrinkage in patients with Alzheimer's disease who received the nutrient cocktail than in those in the control group, which represents a significant slowing in the rate of brain atrophy. The positive effects of the treatment were most pronounced in those patients who began taking the multinutrient formulation at the earliest prodromal stage of Alzheimer's disease”, said Tobias Hartmann.
https://www.eurekalert.org/pub_releases/2020-11/su-lfb103020.php
