Research Projects

The RECAGE project will tackle one of the most challenging problem arising during the clinical course of dementia: the so-called Behavioural and Psychological Symptoms of Dementia (BPSD). The current state-of-the-art of the treatment of these symptoms is still unsatisfactory and there are many unmet needs in this area. The major objective of the...

There are many efforts at European level to improve our ability to monitor health and to prevent, detect, treat and manage disease so that active and healthy ageing can be promoted. In this project, breakthrough research and radical innovation on new services for integrated care is achieved by means of an efficient and cost-effective service...

'Exosomes are small vesicles which mediate cell-cell communication by transporting across the extracellular environment specific “packages” of RNA and proteins. Importantly, exosomes carry translation initiation factors (TIFs) and miRNAs, a class of short non-coding RNAs with regulatory activity on the expression of the transcriptome of a cell. In...

BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical...

New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise...

Challenge. Caring for the increasing numbers of people across Europe with advanced dementia and palliative care needs who live in care homes is difficult and demanding. People with advanced dementia can be immobile, non-verbal and unable to take part in day-to-day activities. They can be unsettled or agitated, with low quality-of-life and elevated...

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disease with four main pathological changes in the brain: amyloid plaques, fibrillary tau tangles, inflammation and neuronal loss. Phagocytes around amyloid plaques in late onset AD (LOAD) may be neurotoxic but have limited motility and phagocytic activity, suggesting a...

Assemblies of tau and α-synuclein were shown to spread along interconnected neuronal networks suggesting broadly relevant therapeutic directions for Alzheimer’s and Parkinson’s disease. This requires a pre-clinical stage of development that has yet to be met. The scale of neurodegenerative disease burden in Europe calls for an unprecedented...

ProACT targets Europe’s 50 million multimorbid patients to proactively self-manage and offset the EU’s annual €700billion cost of chronic disease management. ProACT aims at providing and evaluating an open application programming interface to integrate a variety of new and existing technologies to advance ‘home based’ integrated care (IC). Cloud...

Internet-based and micro technologies have changed the way we live. But elderly people receiving care have not always benefited from these developments. IntegrAAL uses technology to help improve care for older people. Older people are often cared for by many different people, known as a circle of care. This circle may include informal carers as...

Dementia raises complex challenges for people with dementia, their families, and society. The European Parliament has called for investment in high quality, innovative technology research to improve dementia care but so far there has been little benefit because research has generally been limited, small scale and methodologically flawed. In...

The overall aim is to further the understanding of the BBB in health and disease states towards the development of innovative brain delivery systems, especially for biopharmaceuticals (e.g., peptides, antibodies, etc.) and the identification of novel disease drug targets (Alzheimer’s Disease, MS, metabolic disease).

The related key deliverables...