Research Projects

In recent years, it has been demonstrated that sleep not only plays a crucial role in cognitive, emotional, and immunological functions but also helps to clear the brain from metabolic waste products via the recently discovered glymphatic system. A physiological marker closely associated with glymphatic clearance is electroencephalographic (EEG)...

The goal of Project RELIEVE is to build the very first non-invasive effective closed-loop monitoring and intervention system for brain-related disorders. The outcomes can be used to treat or manage various psychiatric and neurological disorders. We do this by pushing the technological boundaries in two separate domains. (1) AI domain: We develop a...

The increased prevalence of Alzheimer’s disease (AD) in our ageing society constitutes an urgent, far-reaching public health concern. In the worldwide effort to identify leverage points to prevent or delay the onset of AD, sleep has recently emerged as a potent modifiable factor to slow down the hallmark pathophysiological processes of the disease...

FreeWalker will integrate several proven components of AAL assistive devices and technologies, for a flexible and versatile solution for guiding and monitoring elderly or impaired persons in the outdoor environment and supporting caregivers by providing emergency information to recover disoriented persons safely. The primary target groups in...

Alzheimer’s disease (AD) is a devastating disorder without a cure. Recent research demonstrates a link between AD and exposure to high levels of air pollution, yet detailed understanding of the connection does not exist. Air pollution, a massive public health issue known to pose a major threat to humans, is an increasing global concern. Researchers...

The EU population is increasingly exposed to new physical and chemical agents in the environment, some of which may be detrimental to public health. Of these, electromagnetic fields (EMF) are one of the most ubiquitous, with new EMF technologies and novel applications being actively developed and commercialised. To address pertinent questions on...

Diabetes mellitus, hypertension, obesity, hypercholesterolemia, smoking and physical inactivity are common in elderly persons and are all associated with an increased risk of myocardial infarction, stroke and dementia. Efficacious treatments of these cardiovascular diseases are available, but in elderly patients with multiple cardiovascular...

How can we understand one another? Our everyday conversations appear to revolve around our linguistic abilities. But creating mutual understanding involves more than formulating grammatically correct sentences. Recently, cognitive science has shown that mutual understanding relies on shared knowledge and beliefs, conceptual knowledge that is...

The RECAGE project will tackle one of the most challenging problem arising during the clinical course of dementia: the so-called Behavioural and Psychological Symptoms of Dementia (BPSD). The current state-of-the-art of the treatment of these symptoms is still unsatisfactory and there are many unmet needs in this area. The major objective of the...

There are many efforts at European level to improve our ability to monitor health and to prevent, detect, treat and manage disease so that active and healthy ageing can be promoted. In this project, breakthrough research and radical innovation on new services for integrated care is achieved by means of an efficient and cost-effective service...

The majority of the risk to develop Alzheimer's disease is influenced by genetic factors. We previously found that carrying a genetic mutation in the SORL1 gene can lead to a greatly increased chance of developing Alzheimer's Disease. SORL1 is involved in the production and processing of Alzheimer proteins that accumulate in the brain. e have...

BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical...