LIGHT study

Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial

Conditions

Prodromal/Mild Cognitive Impairment due to Alzheimer’s disease

Sponsor

Maastricht University

Clinical Trial

Lifestyle behaviour & intervention

Status

Currently recruiting

Drug

Personalised lifestyle intervention

Countries

Netherlands

Information about the intervention that will be tested in the study

Administration

The lifestyle intervention comprises three parts: 1) three individual consultations with a trained lifestyle coach, 2) a voucher program to encourage brain healthy activities, and 3) an access to an online self-management tool for dementia risk reduction.

Will all participants receive the same intervention?

Participants will be selected at random to either receive one of the following options:

A tailored lifestyle intervention (Group A)
General health advices (Group B).

Neither the participant nor their doctor will know if the person is receiving the lifestyle intervention or general health advices.

Information about participating in the trial

What are the researchers trying to find out?

The purpose of the study is to compare an innovative 1-year lifestyle intervention with care as usual and general health advice in older people with Subjective Cognitive Decine (SCD) or Mild Cognitive Impairment (MCI), and to identify possibilities, barriers, and facilitators for sustainable implementation of the lifestyle intervention.

How long will the treatment last?

1 year

What your involvement will entail?

During the study, participants will be asked to complete a test assessing dementia incidence (LIBRA). This test is a weighted score of fifteen lifestyle-related risk factors that are proven to be associated with increased dementia risk. Higher score means a greater risk for dementia
To complete additional tests to assess cognitive functions (e.g., episodic memory, executive functions, information processing speed and attention) and health-related quality of life and capabilities and instrumental activities of daily living
To complete some laboratory tests (e.g., blood test, blood pressure).

Further information on the procedures, tests and visits can be obtained from the study team.

Who can participate in this study?

Who can participate in the study?

To take part in the study, participants must:

Be 50 years old or older
Have a diagnosis of subjective cognitive decline (SCD) or mild cognitive impairment (MCI)
Have a presence of at least 2 modifiable risk factors for dementia (e.g., smoking, obesity, diabetes, high blood pressure, hearing loss).

Who cannot participate in the study?

People cannot take part in the study if they have or have experienced:

A diagnosis of dementia
Insufficient understanding of the Dutch language
A disease or condition that may interfere with the safety, tolerability and/or study assessments (e.g., under treatment for current malignant diseases, major psychiatric disorders like major depression, psychosis or bipolar disorder)
Current participation in another research intervention trial.

The above list is not exhaustive. It includes the most common conditions and diseases that might exclude people from the study.