The University of Pittsburgh (US) has received a grant of USD 2.6 million from the National Institutes of Health (NIH) to study how biological factors such as sex differences contribute to cognitive impairment and dementia. Bistra Iordanova, assistant professor at the University of Pittsburgh will work on this project to see how sex differences influence the neural activity and changes in cerebral blood flow. She will also study how hormonal changes during ageing may affect the energy consumption of the brain.
"One reason it is difficult to understand the sex-based distinctions in dementia is because in a significant portion of the human studies, the gender is regressed out, and the data are pooled together to increase the effect size. Our approach will examine the gene expression of individual cells and use brain imaging to determine the specific cell types that contribute to neurovascular resilience", said Bistra Iordanova.
https://www.eurekalert.org/pub_releases/2020-05/uop-etn052820.php
