On 26 March, Liang Jin and colleagues from Monash University in Parkville (Australia) published a paper suggesting that people with Alzheimer’s disease (AD) may need a different dosage of drugs than that prescribed for other conditions. Findings were reported in the journal ACS' Molecular Pharmaceutics.
Using mouse models, the researchers investigated the absorption process of compounds across the digestive tract into the bloodstream. They showed that AD mouse models had less compounds in their plasma compared to the control mouse models. They reported that the intestinal drug transporters may be disrupted in AD.
Authors of the published study suggested that dosages might need to be adjusted for people with AD to ensure that their plasma concentrations remain effective. People with AD are often prescribed multiple drugs for other conditions such as hypertension and diabetes. These medicines are prescribed to people with AD using the same dosing regimens as those used in people without AD.
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.9b01227
