Researchers suggest that blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction


On 14 January, US researchers from the University of Southern California in Los Angeles reported a link between neurovascular dysfunction and human cognitive dysfunction. 161 cognitively normal adults and with early cognitive dysfunction (≥ 45 years of age) were included in the published study showing that people with early cognitive dysfunction develop brain capillary damage and blood–brain barrier breakdown in the hippocampus, independent of tau and amyloid biomarkers changes which are the classic pathophysiological hallmarks of Alzheimer’s disease. Researchers suggested that blood–brain barrier breakdown is an early biomarker of cognitive impairment and that neurovascular dysfunction may represent a factor contributing to early cognitive dysfunction. Findings were published in the journal nature medicine.