On 25 February, US researchers from the University of Michigan published an article on sex differences in cognitive decline disorders in the journal JAMA Network Open. In the published study, scientists used data from 26,288 participants, including 11,775 men and 14,913 women. All participants had no history of dementia or stroke at baseline and no incidence of dementia or stroke before the first cognitive assessment.
The primary outcome was change in global cognition. Secondary outcomes were change in memory and executive function. Looking at the results from the analyses, the team found that women had significantly higher baseline performance than men in global cognition, executive function and memory. Compared with men, women had significantly faster declines in global cognition, executive function but not in memory.
The scientists therefore suggested that women may have greater cognitive reserve but faster cognitive decline than men, which could contribute to sex differences in late-life dementia.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2776902?resultClick=3
