On 3 June, US researchers from the University of New Mexico reported the development of a vaccine that may prevent the formation of Tau accumulation in the brain. Results were published in the journal NPJ Vaccines. In the published study, scientists developed a vaccine with virus-like particles and tested it one of the most pathologically aggressive mouse models of tauopathy. Tauopathies including frontotemporal dementia and Alzheimer’s disease are progressive neurodegenerative diseases associated with the aggregation of Tau protein in the brain. Researchers found that when the vaccine was given to animals, they developed antibodies that reduce levels of the Tau proteins and prevent neuronal cell death. Using learning and spatial memory tests, they also showed that vaccination could improve cognitive functions.
Researchers develop vaccine that could reduce accumulation of Tau in mouse models
03/06/2019