A new article entitled “Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer’s Disease (EPAD) cohort” has recently been published in the journal Alzheimer’s Research and Therapy. The published study showed that Hormone Replacement Therapy (HRT) use is associated with better memory, cognition and larger brain volumes in later life among women carrying the APOE4 gene, the strongest risk factor gene for Alzheimer’s disease. The research team found that HRT was most effective when introduced early in the menopause journey during perimenopause. Prof Anne-Marie Minihane, from UEA’s Norwich Medical School and director of the Norwich Institute for Healthy Aging at the University of East Anglia (UEA), led the study in collaboration with Prof Craig Ritchie at the University of Edinburgh.
The research team studied data from 1,178 women participating in the European Prevention of Alzheimer’s Dementia (EPAD) initiative to analyse the impact of HRT on women carrying the APOE4 genotype. Congratulations to all authors: Rasha N. M. Saleh, Michael Hornberger, Craig W. Ritchie and Anne Marie Minihane.
You can read the press release from the University of East Anglia here.
You can read the published paper here: https://doi.org/10.1186/s13195-022-01121-5