EU Joint Programme on Neurodegenerative Disease Research (JPND) opens 2022 call on understanding the mechanisms of non-pharmacological interventions


Neurodegenerative diseases (NDs) are debilitating and largely untreatable conditions that are strongly linked with age. Worldwide, there are estimated to be 50 million people with Alzheimer’s disease and related disorders, the most common class of neurodegenerative diseases. This figure is expected to double every 20 years as the population ages. The total direct and informal care costs of Alzheimer’s, Parkinson’s and related disorders are expected to surpass EUR 350 billion per year across the European Union. Existing treatments for neurodegenerative diseases are limited in effect and mainly address the symptoms rather than the cause or the progressive course. With this in mind, The EU Joint Programme – Neurodegenerative Disease Research (JPND) has identified a pressing need for investment aimed at enabling research projects on understanding the mechanisms of non-pharmacological interventions, and on 4 January 2022, launched a transnational call for proposals.

Several non-pharmacological interventions have been shown to be effective and accepted by people living with NDs, e. g. from existing cohort data. Such interventions may include, among others, psychosocial interventions, neuromodulation, nutrition or exercise. Although NDs are recognised as multifactorial syndromes, there is little interaction between biomedical and psychosocial approaches. One rationale for integrating biomedical and psychosocial research is the discordance between neuropathology and cognitive functioning. However, there is yet little knowledge about the mechanisms of non-pharmacological interventions, e. g. at the molecular or cellular levels. This transnational call invites proposals for ambitious, innovative, multinational and multidisciplinary collaborative research projects with a view to promoting research aimed at improving the understanding of the mechanisms and biological substrates that underlie non-pharmacological interventions, in order to tailor a holistic personalised treatment approach. The total funding made available for this call is about EUR 19 million. The pre-proposal submission deadline is 1 March 2022 and full proposals must be submitted no later than 12:00h C.E.S.T. on 28 June 2022, via the electronic submission tool.

For more information about the call, see: