The members of the Amyloid Imaging to Prevent Alzheimer’s Disease (AMYPAD) initiative reached a significant milestone with the enrolment of the 1.000th research participant in its Prognostic and Natural History Study (PNHS). In this clinical study, researchers aim at understanding the role of amyloid imaging in the earliest stages of Alzheimer’s disease to increase the chances of successful secondary prevention trials. The study recruits individuals suspected of possible Alzheimer’s disease from various ongoing European parent cohorts.
Recruitment started in late 2018 and is expected to continue until March 2022. By the end of May 2021, 1.471 participants have been informed about the study, 1.001 consented, and 835 already underwent their amyloid PET scan. At this moment, the PNHS has 17 active sites and 7 cohorts have been actively enrolling into the study (EPAD LCS, EMIF-AD, ALFA+, FACEHBI, FPACK, UCL-2020-412, Microbiota), with two other confirmed to begin enrolment soon. It has also been very rewarding, since a new cohort (Microbiota) has joined the AMYPAD PNHS study and started recruitment. Finally, the data integration process (from all data sources) and quality check of data has been initiated and the team has also conducted the first exploratory analyses of PNHS data.
The AMYPAD project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115952. The Joint Undertaking receives support from the European Union’s Horizon2020 research and innovation programme and EFPIA. This article reflects the author’s view and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein.
