Research Projects

Multiple human diseases ranging from neurodegenerative disorders (such as Alzheimer´s disease) to cancer have been found to be linked with biomolecular mechanical properties change (phase transitions PTs). While these diseases have impacted many human beings (50 million for only AD), the causes of most of these diseases are still mysterious, and...

Current theories of declarative memory suggest that it is supported by two complementary memory systems: the medial temporal lobe (MTL) which specializes in rapid acquisition of novel associations and the neocortex, which slowly learns through environmental regularities. Gilboa et al. recently reported an extraordinary phenomenon of rapid...

'Our memories define who we are and allow us to live independently. Conscious memory is commonly split into two components; “episodic memory” for events that are specific in time and place, and “semantic memory” for our conceptual knowledge about the world. The acquisition of both episodic and semantic memories depends upon the hippocampal...

FERROptosis inhibitors for NEUROdegenerative disorders (NeuroFerro) will focus on the development of potent compounds with improved pharmacokinetic properties, including blood-brain barrier (BBB) permeability for future application in the treatment of neurodegenerative disorders. Ferroptosis is non-apoptotic programmed cell death that has been...

The general objective of the conference is to get a high level political commitment at the EU level to fight against the Alzheimer`s disease and related disorders which is a major public health threat.

The goal of Project RELIEVE is to build the very first non-invasive effective closed-loop monitoring and intervention system for brain-related disorders. The outcomes can be used to treat or manage various psychiatric and neurological disorders. We do this by pushing the technological boundaries in two separate domains. (1) AI domain: We develop a...

The conference objective is to bring stakeholders together to discuss major brain diseases, i.e. stroke and Alzheimer disease in the societal context in order to highlight the imbalance between the societal and individual costs of brain disease, and the resources allocated to dealing with the problem, and to help build a more coordinated European...

Critical to our understanding of Alzheimers disease (AD) and other neurodegenerative dementias (NDDs), as well as to finding disease-modifying therapies, is the development of biomarkers for the underlying disease processes. To facilitate improved diagnostics and drug discovery, we have developed methods to measure markers of amyloid and tau...

Since Alzheimer disease (AD) affects up to 50% of individuals above 85, we will witness the three-fold increase in the number of patients by 2050 if no efficient therapy will be found. The FLORIN offers non-invasive real-time monitoring of key mechanisms involved in the AD pathogenesis by avant-garde bioimaging at temporal resolution less than 1...

Over half of Parkinson Disease patients develop cortical dysfunctions leading to Parkinson Disease Dementia (PDD). The cognitive changes are primarily driven by pathological alpha-synuclein (a-syn) protein aggregates with secondary synaptic dysfunctions in the cortex. Microglia plays a key role in synapse maintenance and clearance of aggregated a...

The increased prevalence of Alzheimer’s disease (AD) in our ageing society constitutes an urgent, far-reaching public health concern. In the worldwide effort to identify leverage points to prevent or delay the onset of AD, sleep has recently emerged as a potent modifiable factor to slow down the hallmark pathophysiological processes of the disease...

Follow.Me aims to satisfy people’s desire of monitoring the position of elderly people with different forms of dementia and Alzheimer, in order to prevent danger situations. Caregivers and family members will be able to track their patients and loved ones using geofencing technologies in order to know when they leave or enter a given area, the...