Research Projects

MedGUIDE is a European innovation project that provides an innovative approach to support seniors with dementia with their medication adherence through smart pill boxes and social networking. The project aims to help elders with mild cognitive impairments living at home

Protein aggregation is associated with some of the most prevalent and devastating neurodegenerative disorders in our society, including Alzheimer’s and Parkinson’s diseases. The intricate details of the aggregation process are now beginning to emerge through major efforts for characterizing the associated protein deposits . However, knowledge about...

Peptide-lipid interactions are critical in several biomedical matters that seem uncorrelated at a first glance. MEMPEPACROSS deals with some of these: 1) Lipid membrane-interactions are the key for the understanding of dengue virus assembly and can constitute a target for its inhibition. Viral hemorrhagic fever caused by dengue virus is a serious...

MEMENTO provides a solution to help people with dementia to life with a decline of memory – short term memory as well as long term memory. MEMENTO provides a tool to create own set of memories in everyday life. It’s your own picture, voice and video diary. MEMENTO addresses people with early and middle level of dementia such as those subjects with...

Advances in neuroscience have returned the focus on learning, placing the relationship between sleep and consolidation of memory at the centre of academic debate. There are two types of sleep: rapid eye movements and slow wave sleep (SWS). Although both types of sleep have been related to memory consolidation, accumulated evidence points more to...

MEMOSAD aims at defining the molecular mechanisms of Abeta- and Tau-induced synaptotoxicity and at developing disease-modifying therapeutics for the prevention of memory loss in Alzheimer disease (AD). Insoluble aggregates of the two proteins provide the pathological hallmarks of this incurable brain disorder. Early stage AD is characterized by a...

In M-GATE, ESRs will combine state-of-the art experimental neurophysiology, innovative technologies, and advanced theoretical approaches to unveil memory mechanisms, from single neurons to brain networks, to cognition and behaviour, addressing the healthy and diseased brain. Through research and training from top-class scientists and close...

Alzheimer disease (AD) is the most common form of age-related dementia affecting millions of patients worldwide. Disturbingly, disorders of lipid and glucose metabolism emerge as major risk factors for onset and progression of neurodegeneration in the human population. Thus, an increasing life expectance combined with an observable rise in...

Research on dementia discourse has shown how our attitudes, views and words have a positive or negative influence on the well-being of People Living With Dementia (PLWD). In 2013, Alzheimer Europe’s report underlined worrying ethical risks of metaphor use in dementia narratives, including stigmatisation, stereotyping and social exclusion. Yet we...

Memories are important for dementia patients; they influence how they act and feel nowadays. However, for people around them, it is often hard to explore what is really going on in their beloved one’s mind. In MI-Tale we develop a digital and interactive game to recall and record memories. This tool contains existing material such as historical...

Alzheimer’s disease (AD) affects over 55 million people worldwide, with no effective treatments currently available. Understanding early-stage mechanisms of the disease is critical to developing new therapeutic approaches. Microglial cells, key regulators of amyloid-beta (Aβ) clearance and neuroinflammation, are implicated in the progression of AD...

What is the relation between the intestinal microflora and the brain in the development of neurodegenerative disorders like Alzheimer's and Parkinson's disease? A functional relation between the intestinal microflora (microbiota) and the brain, referred to as the “microbiota-gut-brain axis”, was hypothesized more than 100 years ago but only...