Research Projects

IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and  (II) the focused application of this pipeline to derive clinically...

Health scientific discovery and innovation are expected to quickly move forward under the so called “fourth paradigm of science”, which relies on unifying the traditionally separated and heterogeneous high-performance computing and big data analytics environments. Under this paradigm, the DeepHealth project will provide HPC computing power at the...

Independent living of senior citizens is one of the main challenges linked to the ageing population, due to the impact on: (a) the life of the elderly people, (b) the national health systems, (c) the insurance companies, (d) the relatives and (e) the care-givers. Senior citizens may suffer from a number of diseases, including the decline in...

Follow.Me aims to satisfy people’s desire of monitoring the position of elderly people with different forms of dementia and Alzheimer, in order to prevent danger situations. Caregivers and family members will be able to track their patients and loved ones using geofencing technologies in order to know when they leave or enter a given area, the...

Joint Action on Dementia 2015-2018. The Joint Action will focus on two phases on work: approximately 12 months on developing a consensus on the best evidence of effective action in 4 key areas (diagnosis and post-diagnostic support; crisis and care coordination; quality of care in residential care settings; and dementia-friendly communities); and...

Every year, Alzheimer's disease (AD) affects about 800,000 new patients in Europe and directly causes 50% of dependency of aged persons. Currently there is no test to diagnose this disease. There is a great need to improve outcomes for patients with lung cancer which causes between 15-28% of all cancer deaths in Europe. Chemical and structural...

Across Europe there is an increasing shift from centralized intramural care to decentralized extramural care, with a major role and responsibility for care organisations to provide care in the community and tools to support independent living. In the MagicTABLE project we want to bring the intramural serious game system, the ‘Tovertafel’, to the...

MedGUIDE is a European innovation project that provides an innovative approach to support seniors with dementia with their medication adherence through smart pill boxes and social networking. The project aims to help elders with mild cognitive impairments living at home

The aim of CONFIDENCE is to develop a community-based mobility safeguarding assistance service for people suffering from mild to moderate dementia. CONFIDENCE combines “assistive technologies” with “personal help”. The CONFIDENCE service is built around a “virtual companion” providing different levels of assistance, depending on the situational...

Imaging of distribution of drugs in mice delivers accurate information for confirmation that the mechanism of action elaborated in cell-based assays is also operative in vivo. These data are critical for the transfer of drug discovery process from pre-clinical to clinical phase. To enable the imaging, drugs should be labeled with easily detectable...

The objective of the PETAL Project is to provide a platform able to increase elderly autonomy and assist them in carrying out activities of daily living. In particular, we aim to support older adults affected by mild dementia with useful and usable means to increase their awareness and control of their current lifestyle by providing them with...

The annual worldwide cost of Alzheimer’s dementia was 777.81 billion Euro in 2015. This number will rise to 7.41 trillion Euro in 2050. Early diagnosis would save up to $7.9 trillion in medical and care costs by 2050 in the US alone. However, the emergent pathology is highly variable across people, necehighly variable across people, necessitating...