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VPH Dementia Research Enabled by IT


Start Date
End Date
Total Funding
€ 17 899 289
Funding Programme

The DementiA Research Enabled by IT project responds to the European Parliament's 2011 resolution for a European Initiative on Alzheimer's disease and other dementias, and the EU Year of the Brain 2014 Initiative. It delivers the first patient-specific predictive models for early differential diagnosis of dementias and their evolution. Its mechanistic/phenomenological models of the ageing brain account simultaneously for the patient-specific multiscale biochemical, metabolic and biomechanical brain substrate, as well as for genetic, clinical, demographic and lifestyle determinants. It investigates the effect of metabolic syndrome, diabetes, diets, exercise, and pulmonary conditions on the ageing brain, as environmental factors influencing onset and evolution of dementias.
An integrated clinical decision support platform will be validated/ tested by access to a dozen databases of international cross-sectional and longitudinal studies, including exclusive access to a population study that has tracked brain ageing in more than 10,000 individuals for over 20 years (Rotterdam Study).
Enabling more objective, earlier, predictive and individualised diagnosis and prognosis of dementias will support health systems worldwide to cope with the burden of 36M patients that, due to ageing societies, will increase to 115M by 2050. Worldwide costs are estimated to €450B annually. In 2012, the WHO declared dementia a global health priority.
Our consortium assembles highly recognised engineering, physical, biomedical and clinical scientists, and industrial partners experienced in exploiting VPH technologies in healthcare. Co-operation with infrastructure projects like VPH-Share, related international Physiome efforts, and other dementia research consortia is assured, allowing European researchers from different disciplines to contribute to share resources, methods and generate new knowledge.

Project partners

Empirica Gesellschaft Fur Kommunikations Und Technologieforschung Mbh
Asd Advanced Simulation And Design Gmbh
Imperial College Of Science Technology And Medicine
Tomorrow Options Microelectronics S.A.
Teknologian Tutkimuskeskus Vtt Oy
Philips Technologie Gmbh
Esi Group
Universiteit Maastricht
Eibir Gemeinnutzige Gmbh Zur Forderung Der Erforschung Der Biomedizinischen Bildgebung
Fondazione Ospedale San Camillo
Eidgenoessische Technische Hochschule Zuerich
Universitetet I Oslo
Klinik Hirslanden Ag
Combinostics Oy
The Chancellor
Masters And Scholars Of The University Of Oxford
Erasmus Universitair Medisch Centrum Rotterdam
University College London
Philips Medical Systems Nederland Bv
Ita-Suomen Yliopisto
Philips Gmbh
Teknologian Tutkimuskeskus Vtt
King'S College London
Sheffield Teaching Hospitals Nhs Foundation Trust
The University Of Sheffield

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).