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Targeting epigenetic dysregulation in the brainstem in Alzheimer’s disease


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European Countries Involved

We aim to elucidate the exact role of epigenetic dysregulation in the brainstem in the pathogenesis of AD. For this purpose, we will examine post-mortem brainstem tissue derived from AD patients, and matched controls, for epigenetic differences. By investigating AD-specific epigenetic profiles in the blood of individuals suffering from Mild Cognitive Impairment (MCI), we aim to determine the predictive (biomarker) value of selected epigenetic signatures.Furthermore, we will test a novel model for AD using neuronal cells generated from the blood cells of AD patients. By doing so, we aim to fill the vital gap in our understanding of the link between stress, epigenetic dysregulation and the development of AD, which may lead to novel targets to better diagnose, prevent, attenuate or possibly reverse the pathophysiology of this disorder.

Project partners

Maastricht University

University of Exeter

University of Würzburg

University of Bonn

German Center for Neurodegenerative Diseases

Luxembourg Centre for Systems Biomedicine

Bellvitge Biomedical Research Institute

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).