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Genomic Instability in Alzheimer’s Disease and Related Disorders: a Single-Cell Approach


Start Date
End Date
Total Funding
€ 1 837 608
Funding Programme
European Countries Involved

Increasing evidence suggests that the genetic information in our bodies can vary from cell to cell. Such variation has also been found in the brain, although its consequences for brain function or disease remain largely unknown. In this project, we will study the role of genomic instability in Alzheimer's disease and related tauopathies. The INSTALZ consortium aims to understand how altered stability of the neuronal genome in the developing and adult brain determines the risk of developing these chronic disorders in late adulthood. In particular, we will investigate how and when during life this cell-to-cell genomic variation could be generated by applying single-cell sequencing of neurons derived from patient brains and several mouse and fly models. The expected impact is to genetically explain the pathogenesis of a consistent part of sporadic cases, for which no pathogenic cause is yet known and to discover the underlying molecular mechanisms that will lead to new early therapeutic tools.

Project partners

Université de Lille

Centre de Recherche Jean-Pierre Aubert

Sanger Institute-EBI Single-Cell Genomics Centre

KU Leuven

Copenhagen University

KTH Royal Institute of Technology

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).