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EURO-FINGERS multimodal precision prevention toolbox for dementia in Alzheimer’s disease


Start Date
End Date
Total Funding
€ 1 800 000
Funding Programme
European Countries Involved

Prevention of Alzheimer’s disease (AD) and dementia is a global public health priority. EURO-FINGERS builds upon the successful experiences of two multimodal prevention trials: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) and the JPND-funded MIND-AD. The FINGER intervention trial showed that a multimodal lifestyle intervention consisting of nutritional guidance, exercise, cognitive training, and control of vascular risk factors benefitted cognition in seniors at increased risk of dementia. In MIND-AD, this model has then been tested for the first time also in subjects with early-symptomatic (prodromal) AD.

EURO-FINGERS will leverage these and other European data to develop tools enabling Precision Prevention for dementia and AD. These tools include methods to accurately measure the level of AD risk in seniors, and their prevention potential. In fact, there is no “one-size-fits-all” solution: to be effective and sustainable, preventive strategies need to be tailored to specific risk groups, identified by clinical and biological features, and environmental risk factors exposure. EURO-FINGERS will also develop an innovative trial model, combining multimodal lifestyle interventions with drugs that might halt AD. This include a tool (EURO-FINGERS online registry) to easily direct research-interested citizens/patients to the most suitable prevention trials.

Furthermore, through their active engagement in EUROFINGERS, the project aims to empower subjects at risk (or early-stage) of AD dementia, by integrating their views and preferences in guidelines on how clinicians should disclose the at-risk status. The project will also identify strategies for shared decision-making, to improve patients and caregivers involvement in the diagnostic process and the choice of preventive strategies.

Project partners

Karolinska Institute

National Institute for Health and Welfare

Saarland University

VU Medical Center

IIS Instituto Hospital del Mar de Investigaciones Mèdicas

Alzheimer Europe

National Institute of Clinical Neurosciences

Semmelweis University Budapest

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).