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Brain barriers training


Start Date
End Date
Total Funding
€ 3 067 402
Funding Programme

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.

Project partners

Universitaet Bern
Stichting Vu
Ruprecht-Karls-Universitaet Heidelberg
Ecole Polytechnique Federale De Lausanne
Universite Libre De Bruxelles
Szegedi Biologiai Kutatokozpont
Stichting Vumc
Johann Wolfgang Goethe-Universitatfrankfurt Am Main
Genxpro Gmbh
The Open University
Universite D'Artois
Ifom Fondazione Istituto Firc Di Oncologia Molecolare
F. Hoffmann-La Roche Ag
Lavision Biotec Gmbh
Ncardia Bv
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev
Rains For Brain Foundation Onlus
University Of San Diego
Scitec-Media Gmbh
Tp21 Gmbh

Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).