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Gamma tACS

Non-invasive neurostimulation as a tool for diagnostics and management for neurodegenerative diseases

Kuopio University Hospital
Gamma tACS (transient alternating current stimulation)

Information about the intervention that will be tested in the study


The intervention will be administered via a brain stimulation on the posterior parietal cortex (this means that electrodes are placed on the scalp over the specific area of the brain named posterior parietal cortex).

Will all participants receive the same intervention?

Participants will be selected at random to either receive one of the following options:

  • Brain stimulation of gamma tACS over the superior parietal cortex
  • Brain stimulation of sham over the superior parietal cortex (also called a dummy intervention which is an inactive brain stimulation identical in appearance to the intervention being tested with no active therapeutic effect).

Neither the participant nor their doctor will know if the person is receiving the active brain stimulation or not.

Information about participating in the study

What are the researchers trying to find out?

The purpose of the study is to evaluate whether repeated stimulation with gamma tACS on the posterior parietal cortex can improve symptoms in people with neurodegenerative diseases, including dementia with Lewy Bodies, Alzheimer's disease, idiopathic normal pressure hydrocephalus and Frontotemporal dementia.

How long will the study last?

Brain stimulation once a day during four consecutive days

What your involvement will entail?
  • Participants will be asked to complete several tests to assess verbal learning, memory, recognition and orientation

Further information on the procedures, tests and number of visits can be obtained from the study team.

Who can participate in this study?

Who can participate in the study?

To take part in the study, participants must:

  • Be 18 years old and older
  • Have a diagnosis of mild cognitive impairment due to Alzheimer's disease, dementia with Lewy Bodies or frontotemporal dementia
  • Be patient of the Kuopio University Hospital Neuro Center.
Who cannot participate in the study?

People cannot take part in the study if they have:

  • History of seizures (this is uncontrolled electrical disturbances in the brain)
  • Pregnancy
  • Metal implants in the head (except dental fillings)
  • Electronic implants (i.e. pace-maker, implanted medical pump).

The above list is not exhaustive. It includes the most common conditions and diseases that might exclude people from the study.

Information for your doctor identifier


Study contact information

Eino Solje +358 17 713 311

Link to full text

The information contained in this document is based on information available on public registries (e.g. website) on January 2023.

This document has been reviewed by the institution running this trial.


Alzheimer Europe's Clinical Trials Watch database was developed as part of the 2018 Work Plan which received funding under an operating grant from the European Union’s Health Programme (2014–2020).

Alzheimer Europe gratefully acknowledges the support of its corporate sponsors for the update and maintenance of the database.