There is, as yet, no cure available for dementia and Alzheimer disease (AD). With prevention therefore being identified as a global priority, the EU-FINGERS consortium will work towards a novel multimodal precision prevention toolbox, based on an existing successful multimodal lifestyle/vascular prevention model, FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) and on a precision prevention and early detection (PPED) approach, adapted from cancer research.

The EU-FINGERS Toolbox will include the full range of tools needed to start the next generation of AD dementia prevention trials, within the framework of precision medicine. The aim is to deliver targeted and timely interventions to effectively prevent/delay dementia. The Toolbox will also provide a common framework and align main European cohorts in the AD research field, to deliver results easily implementable in Europe.

The project will align multinational cohorts from observational studies and recent landmark multimodal dementia prevention trials, with new unique long-term trial data. The entire continuum from at-risk and preclinical to prodromal disease stages will be covered, with deep comprehensive clinical, functional and biological assessments.

EU-FINGERS (INTER/JPND/19/BM/14012609) is an EU Joint Programme - Neurodegenerative Disease Research (JPND) project and is supported by the Luxembourg national research fund (FNR).