The Synaptic Dysfunction in Alzheimer Disease (SyDAD) project is about to end. As a really final event, SyDAD organised a symposium at the 14 International Conference of Alzheimer’s and Parkinson’s Diseases (AD/PD) in Lisbon on March 31. Three of the Early Stage Researchers (ESRs) together with five more senior SyDAD members presented their work for a full chamber.
The symposium titled “Synaptic dysfunction in Alzheimer’s disease” ran from 09:45h to 11:45h. The first part included presentations from four senior SyDAD members:
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Monica Di Luca (Italy) – “Targeting ADAM10 synaptic trafficking as therapeutic target for Alzheimer’s disease”
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Gael Barthet (France) – “Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity”
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Susanne Frykman (Sweden) – “Species and developmental difference in processing of the amyloid precursor protein”
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Eckhard Mandelkow (Germany) – “Tau in neuronal compartments: sorting, missorting, transmission, and consequences for synaptic function”
The second part was then dedicated to the ESRs who presented their work:
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Miguel Matias (Belgium) – “Dysfunction of the hippocampal circuit on a Tau seeding mice model”
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Sara Rodrigues (Germany) – “Spreading of Tau pathology in mouse models expressing pro-aggregant vs anti-aggregant Tau”
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Hazal Haytural (Sweden) – “Proteomic alterations in the molecular layer of the dentate gyrus in Alzheimer disease brain”.
Finally, Bengt Winblad (Sweden) gave a final speech on the “novel therapeutics targeting synaptic dysfunction in Alzheimer’s disease”. Juan Diego Pita Almenar (Belgium) and Christophe Mulle (France) made the introductions and chaired the symposium.
