Indian scientists from the Jawaharlal Nehru Centre in Karnataka have developed a new molecule that may reduce the toxicity of amyloid beta, the main component of the amyloid plaques found in the brains of people with Alzheimer's disease (AD). This work has recently been published in the journal Advanced Therapeutics.
The study established the molecule called TGR63 as the lead candidate to rescue neuronal cells from amyloid toxicity. Scientists found that TGR63 treatment showed a significant reduction of amyloid burden in the cortex and hippocampus region of the brain of mouse models and reversed cognitive decline. In addition, mouse models treated with TGR63 showed an amelioration of learning deficiency, memory impairment and cognitive decline.