The FluiDx-AD project, funded by the European Union’s Horizon Europe programme with a budget of EUR 7,699,219.38 over three and a half years, aims to improve early diagnosis and management of Alzheimer’s disease (AD) through three complementary tests. On 9 October 2025, the consortium met in Bologna, Italy, for its General Assembly meeting. The day opened with remarks by Ole Petter Ottersen, Chairman of Pre Diagnostics (Scientific Coordinator), followed by an overview of the exploitation plan with Håkon Sæterøy and a progress update by Project Coordinator Ira Haraldsen (Oslo University Hospital). Vebjørn Andersson (Oslo University Hospital) presented the proposed EU Hop-on Action, which would add a new partner to conduct proteomics analysis of AI-Mind blood samples. If approved, EUR 600,000 would be allocated to expand the dataset and strengthen validation.
Scientific updates followed. Haraldsen and Andersson presented Work Packages (WP)1 and 2, focused on building a unified, anonymised clinical and biomarker database via a secure Services for Sensitive Data (SSD) cloud platform. Praveen Sharma (HemoDx) outlined WP3–5, developing SalivaDx-AD, an at-home saliva test to detect AD risk early. Planned studies include usability testing, reference interval establishment and proof-of-concept validation. Line Amundsen (Pre Diagnostics) covered WP6–8 on PlasmaDx-AD, a minimally invasive blood test for confirmatory diagnosis of AD in individuals with mild cognitive impairment. Maria Donate (Pre Diagnostics) reported on WP9–10 and BloodCellDx-AD, a whole-blood test to assess ARIA risk during immunotherapy, with comparative and proof-of-concept studies planned. Christophe Bintener (Alzheimer Europe) shared updates on communication and dissemination activities, while Faye Forsyth (Alzheimer Europe) outlined Public Involvement plans, including the bespoke Public Advisory Board and a review on ethical and social aspects. The meeting concluded with a presentation by Masha Tippersma (Medip Analytics) on the health economic analysis dashboard, followed by project management updates and next steps.