Cardiovascular health and cognition vary by recruitment route and country in data set from MOPEAD project

03/09/2025

On 3 September, researchers from Slovenia, Spain, Germany, Sweden and the Netherlands published an article on cardiovascular health and cognition in older adults in the Journal of Alzheimer’s Disease journal. Using MOPEAD data, the study included 414 people aged 65–85 at high risk of prodromal or mild Alzheimer’s disease across four recruitment routes: a web-based screening tool, an open house initiative, a primary care early-detection protocol and screening at diabetologist clinics in five countries. Cardiovascular risk factors were self-reported and cognition was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Significant differences in physical activity were observed (p<0.001), with Sweden and Slovenia reporting the highest activity; Dutch participants scored highest on most cognitive measures. Web-based recruits were youngest, most active (61.7%), and had the lowest rates of diabetes (12.0%) and heart disease (6.4%) with the best cognitive scores, while diabetologist-clinic recruits showed the highest cardiovascular risk and the lowest cognitive performance. The open house initiative shows promise for future recruitment in the context of disease-modifying treatments. The article can be read here: https://doi.org/10.1177/13872877251371729