Analysis of Rotterdam study shows that people with low bone mineral density may have a higher risk of developing dementia

21/03/2023

A newly-published analysis of the Rotterdam study of community-dwelling older adults has found an association between low bone mineral density (BMD) and dementia, identifying BMD as a potential indicator of dementia risk in later life. BMD tests such as dual-energy x-ray absorptiometry (DXA) measure the amount of calcium and other minerals in our bones. BMD is affected by parameters such as old age, physical inactivity, sex steroid usage, and vitamin d deficiency. In their recent Neurology journal publication, a team of researchers from the Rotterdam study evaluated the association between BMD (measured at different sites in the body) and dementia risk. In total, DXA scan data from 3,651 participants was obtained between 2002-2006.

Over a median follow-up period of 11.1 years, researchers identified 688 participants who developed dementia, 528 of whom were diagnosed with Alzheimer’s disease (AD). During the follow-up period, participants with lower BMD at the top of the femoral (thigh bone) had a 12% increased likelihood of developing all-cause dementia. No link between lower lumbar spine BMD and dementia was observed. Looking at total body BMD, participants in the lowest tertile for bone density had the highest risk of dementia. Read the full article, here:

https://n.neurology.org/content/early/2023/03/22/WNL.0000000000207220