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Study assesses dementia and mortality in people with Down syndrome

Monday 19 November 2018

On 19 November, an international team of scientists from the United Kingdom, China and Singapore published an article on dementia and mortality among adults with Down syndrome (DS) in the journal JAMA Neurology.

The information for the statistical analyses was gathered through the London Down Syndrome Consortium cohort. The researchers identified 211 people (aged 36 and older) with DS. Using the information on 27 participants that died during the study period, the scientists found that crude mortality rates for individuals with DS and dementia were 5 times higher than for those without.

Furthermore, the team reported that those who carried the APOE ε4 gene respectively had comorbidities were exposed to a higher risk of dementia and death.

While this sample is relatively small with a maximum of 65 months follow-up time, the authors acknowledged that there is a need for further research, which includes more participants during a longer period of time. Nevertheless, the authors stated that the association of multiple diseases and risk of developing dementia as well as mortality risk underlines the need for effective recognition and treatment of common health comorbidities in people with DS.