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Systematic review & Meta-analysis provides estimates of Young-Onset Dementia highlighting that the condition affects almost 4 million worldwide

Monday 19 July 2021

On 19 July, a group of researchers published a new paper on the global prevalence of Young-Onset Dementia (YOD) in the journal JAMA Neurology. This important research aims to provide policy makers with much needed information to organise health care in an appropriate way as the rates indicate the condition to be more prevalent than previously thought. The team used various data bases to identify appropriate population-based studies throughout the past 30 years and thereby identified 95 unique studies. Out of these, 74 contained 5-year age ranges that fed into the meta-analysis.

Th results of the study include an overall estimate of the age-standardized prevalence of YOD of 119.0 per 100 000 population as well as estimates of YOD for 5-year age bands (from 30 to 34 years up to 60-64 years). Taking the United Nations world population of 2019 into account, this estimate translates to 3.9 million people living with YOD throughout the world.

In addition, the researchers report that prevalence between men and women seemed to be similar (slightly higher in women) and that there were differences between high-income countries (crude estimate, 663.9 per 100 000 population) compared with upper–middle income (crude estimate, 1873.6 per 100 000 population) and lower–middle-income (crude estimate, 764.2 per 100 000 population) countries. At the same time, the team highlights that estimates of the prevalence in low-income countries and younger age ranges remain scarce, underlining the need for more population-based studies in these.

Read the full publication here: