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Publication calls to action for a better understanding of the impact of sex and gender in Alzheimer’s disease

Tuesday 12 June 2018

On 12 June, the Society for Women's Health Research Interdisciplinary Network on Alzheimer's Disease published an article on a review of ongoing and published research in the context of sex and gender differences in Alzheimer’s disease (AD) in the journal Alzheimer’s & Dementia.

In their non-systematic review, the international and multidisciplinary team highlights a variety of undertakings, which stress the significance of acknowledging both sex and gender influences. These encompass the examination of epidemiology, clinical presentation, disease progression as well as neurobiological manifestations.

The work, supported by a programmatic grant from Eli Lilly & Co, concludes with a list of recommended priority research areas that warrant future attention from the perspective of the authors:

  • Potential risk factors that affect only one sex, like menopause and pregnancy disorders, and the influence of sex hormones like estrogen on brain function
  • Differences between women and men in risk factors that affect both sexes, like cardiovascular disease, diabetes, exercise, and depression
  • Sex differences in genetic risk factors like APOE ε4
  • Sex and gender differences in racial and ethnic subgroups
  • Gender differences in caregiving and how the burden of caregiving influences AD risk for the caregiver
  • Differences between women and men in response to current AD therapeutics and those in development
  • Differences between women and men in the detection, diagnosis, progression, management, and treatment of AD.

You can find the publication here.