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Alzheimer Europe contributes to paper on complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease

Monday 26 July 2021

On 26 July, researchers from the public-private MOPEAD partnership published an article on complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease in Alzheimer’s & Dementia, the journal of the Alzheimer’s Association.

In the published paper, scientists focused onthe success usingfour complementary pre-screening strategies, namely:

1) a web-based pre-screening tool,

2) an open house initiative,

3) a primary care–based protocol for early detection of cognitive decline, and

4) a tertiary care–based pre-screening at diabetologist clinics.

The team reported that among an overall 2.847 pre-screened individuals, 1.129 (39.7%) people were identified to be at high risk of having prodromal Alzheimer’s disease (AD) or dementia. They also underlined that the corresponding proportion for the different initiatives were differing. The lowest proportion of people identified among participants were those who made use of the web-based pre-screening (36.8%), this was followed by the people who joined the open house initiatives (35.6%). At the same time, the primary care–based protocol led to 44.4% positive cases and the highest positivity rate was observed in the tertiary care–based pre-screening (58.3%).

Looking at age and sex differences, the team noted that “the likelihood of a positive pre-screening result seems to increase with age but was not influenced by sex”. Furthermore, they note that the likelihood of a positive pre-screening differed among participating countries (Slovenia, Spain, Sweden, the Netherlands and Germany). Concluding, the researchers note that the four engagement initiatives were able to identify four individuals at high risk of having prodromal AD or dementia for every 10 pre-screened individuals while also highlighting some differences in the characteristics of participants, depending on the initiative they’ve participated in.

https://doi.org/10.1002/alz.12441

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