Mouse study identifies antibodies which may help to prevent the onset of Alzheimer’s disease

Thursday 09 June 2011

A mouse study suggests that two antibodies, (ICSM-18 and ICSM-35) may be able to block the damaging effects on brain tissue caused by amyloid beta, which is often associated with Alzheimer’s disease. The work was carried at the Medical Research Council Prion Unit at University College London, in collaboration with colleagues at the Laboratory for Neurodegeneration at University College Dublin and Trinity College Dublin. It was published in the journal Nature Communications.

In 2012 clinical trials will commence to determine whether drugs based on the two antibodies are able to mitigate the damage caused to the brarin as a treatment for people with Creutzfeldt-Jakob disease (CJD).

For further information please see the article entitled “Drugs Being Developed To Tackle CJD Could Also Help Prevent Alzheimer's” on the Medical news Today website at:

http://www.medicalnewstoday.com/releases/228009.php

And the research paper entitled “Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites” in the journal Nature Communications at:

http://www.nature.com/ncomms/journal/v2/n6/full/ncomms1341.html