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Cerebral Amyloid Angiopathy (CAA)

Cerebro-Vascular Diseases

by Kurt Jellinger

General outline

A rare form of cerebrovascular dementia caused by amyloid deposits in small-vessel walls which give rise to hemorrhages.


Congophilic angiopathy

Symptoms and course

A combination of neurological and psychopathological symptoms. Stepwise progressive, hemorrhages cause neurological symptoms accompanied by progressive dementia.

Causes and risk factors

Several mutations on the APP gene on Chromosome 21 have been identified in Dutch families.


CAA at a subclinical level can occur in up to 98% of AD and 85% of aged brains.

Diagnostic procedures

Imaging (CCT and MRI) demonstrates the multiple hemorrhages. Genetic testing is used as ApoE [epsilon] 4 is a risk factor.

Care and treatment

Anticoagulants and thrombolysis; rehabilitation after stroke.

Available services

The Cerebral Amyloid Angiopathy (CAA) Resource This website is intended as a resource for both patients and families suffering from CAA and the investigators and clinicians who work in this field.


  • Greenberg: Neurology 51 (1998) 690-94.



Last Updated: vendredi 09 octobre 2009


  • Acknowledgements

    This information was gathered in the framework of the European Commission financed project "Rare forms of dementia". Neither the European Commission nor any person acting on its behalf is responsible for any use that might be made of the following information.
  • European Union


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